Oncolytics Biotech is directing a broad clinical trial program with the objective of developing REOLYSIN® as a human cancer therapeutic. The clinical program includes human trials using REOLYSIN® alone and in combination with radiation and chemotherapy, and delivered via local administration and/or intravenous administration.

Clinical Trial Chart

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Delivery Method Trial Program
and Cancer Indication		 Location Status
Intravenous administration in combination with paclitaxel and carboplatin Phase II head and neck U.S. Approved
Intravenous administration in combination with paclitaxel and carboplatin Phase II head and neck U.K. Ongoing
Intravenous administration in combination with cyclophosphamide Pancreatic, lung, ovarian U.K. Ongoing
Intravenous administration monotherapy (NCI) Phase II melanoma U.S. Recruiting
Intravenous and intraperitoneal administration monotherapy (NCI) Phase I/II ovarian U.S. Ongoing
Intravenous administration monotherapy Phase II sarcomas U.S. Ongoing
Intravenous administration in combination with gemcitabine Pancreatic, lung, ovarian U.K. Ongoing
Intravenous administration in combination with docetaxel Bladder, prostate, lung, upper gastro-intestinal U.K. Ongoing
Intravenous administration in combination with paclitaxel and carboplatin Melanoma, lung, ovarian U.K. Ongoing
Local therapy in combination with radiation Phase II various metastatic tumours, including head & neck U.K. Ongoing
Local therapy in combination with radiation Phase I various metastatic tumours U.K. Complete
Infusion monotherapy Phase I/II recurrent malignant gliomas U.S. Ongoing
Intravenous administration monotherapy Phase I various metastatic tumours U.S. Complete
Intravenous administration monotherapy Phase I various metastatic tumours U.K. Complete
Local monotherapy Phase I recurrent malignant gliomas Canada Complete
Local monotherapy T2 prostate cancer Canada Complete
Local monotherapy Phase I trial for various subcutaneous tumours Canada Complete

Canadian Cancer Society
American Cancer Society
Brain Tumour Foundation of Canada
American Brain Tumor Association
 
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