Oncolytics Biotech is directing a broad clinical trial program with the objective of developing REOLYSIN® as a human cancer therapeutic. The current clinical program includes human trials using REOLYSIN® alone and in combination with chemotherapy or immune modulation, and delivered via local administration and/or intravenous administration. The Company's first pivotal trial will be a Phase III randomized clinical trial examining the intravenous administration of REOLYSIN® in combination with paclitaxel and carboplatin in patients with platinum-failed head and neck cancers.

Participation in Clinical Trials Using REOLYSIN®

REOLYSIN is available in a clinical trial setting only. It is not approved in any jurisdiction and not available for purchase. The Company does not participate in special access programs. Most of the trials are being conducted in the U.S. by Oncolytics and its clinical partners.

The Company and its employees have no influence over the inclusion of a patient in a clinical trial. To obtain a list of U.S. trials currently being conducted using REOLYSIN please visit www.clinicaltrials.gov and search using the term REOLYSIN. Each listing includes patient inclusion and exclusion criteria. If the patient’s physician determines that they might be a suitable trial candidate, they can contact a participating centre; there is contact information near the bottom of each trial listing.

While the Company does have a broad clinical program, it is increasingly focused on specific indications. Patients that cannot find a trial for their specific indication are invited to check the www.clinicaltrials.gov website periodically as the site is updated as new trials are announced.

Clinical Trial Chart

Click on clinical trial for more detailed information

Trial Name Delivery Method Trial Program
and Cancer Indication
Location Status
REO 022 Intravenous administration in combination with FOLFIRI Phase I colorectal cancer U.S. Enrolling
REO 021 Intravenous administration in combination with paclitaxel and carboplatin Phase II squamous cell carcinoma lung cancer U.S. Ongoing
REO 020 Intravenous administration in combination with paclitaxel and carboplatin Phase II metastatic melanoma U.S. Ongoing
REO 018 Intravenous administration in combination with paclitaxel and carboplatin Phase III squamous cell carcinoma of the head and neck U.S., U.K., Belgium Ongoing
REO 017 Intravenous administration in combination with gemcitabine Phase II advanced pancreatic cancer U.S. Ongoing
REO 016 Intravenous administration in combination with paclitaxel and carboplatin Phase II non-small cell lung cancer U.S. Ongoing
REO 015 Intravenous administration in combination with paclitaxel and carboplatin Phase II head and neck U.S. Ongoing
REO 014 Intravenous administration monotherapy Phase II sarcomas U.S. Complete
REO 013 Intravenous administration monotherapy (sponsored by University of Leeds) Translational metastatic colorectal U.K. Ongoing
NCI Trial Intravenous administration monotherapy (NCI) Phase II melanoma U.S. Ongoing
NCI Trial Intravenous and intraperitoneal administration monotherapy (NCI) Phase I/II ovarian U.S. Ongoing
REO 012 Intravenous administration in combination with cyclophosphamide Advanced malignancies including pancreatic, lung, ovarian U.K. Ongoing
REO 011
(Phase II)
Intravenous administration in combination with paclitaxel and carboplatin Phase II head and neck U.K. Complete
REO 011 Intravenous administration in combination with paclitaxel and carboplatin Advanced malignancies including melanoma, lung, ovarian U.K. Complete
REO 010 Intravenous administration in combination with docetaxel Advanced malignancies including bladder, prostate, lung, upper gastro-intestinal U.K. Complete
REO 009 Intravenous administration in combination with gemcitabine Advanced malignancies including pancreatic, lung, ovarian U.K. Complete
REO 008 Local therapy in combination with radiation Phase II various metastatic tumours, including head & neck U.K. Complete
REO 007 Infusion monotherapy Phase I/II recurrent malignant gliomas U.S. Complete
REO 006 Local therapy in combination with radiation Phase I various metastatic tumours U.K. Complete
REO 005 Intravenous administration monotherapy Phase I various metastatic tumours U.K. Complete
REO 004 Intravenous administration monotherapy Phase I various metastatic tumours U.S. Complete
REO 003 Local monotherapy Phase I recurrent malignant gliomas Canada Complete
REO 002 Local monotherapy T2 prostate cancer Canada Complete
REO 001 Local monotherapy Phase I trial for various subcutaneous tumours Canada Complete

Canadian Cancer Society
American Cancer Society
Brain Tumour Foundation of Canada
American Brain Tumor Association


 
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