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Intravenous Administration in Combination with Paclitaxel and Carboplatin In June 2008, Oncolytics announced that it had received approval to commence a U.S. Phase II clinical trial using intravenous administration of REOLYSIN in combination with paclitaxel and carboplatin in patients with advanced head and neck cancers. This trial is a 14 patient, single arm, open-label, dose-targeted, non-randomized, multi-centre trial of REOLYSIN® given intravenously in combination with a standard dosage of paclitaxel and carboplatin. Eligible patients include those with advanced or metastatic head and neck cancer that are refractory to standard therapy or for which no curative standard therapy exists. The primary objective of the Phase II trial is to measure tumour responses and duration of response, and to describe any evidence of antitumour activity. The secondary objective is to determine the safety and tolerability of REOLYSIN® when administered in combination with paclitaxel and carboplatin to patients with advanced or metastatic head and neck cancer. See related press releases and documents: June 20, 2008 - Oncolytics Biotech Inc. Announces U.S. Phase II Clinical Trial Investigating REOLYSIN® in Combination with Paclitaxel and Carboplatin |
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