Scientific Information

Below is a list of selected publications relating to REOLYSIN^® and Oncolytics’ clinical trial program.

Phase II Trial of Intravenous Administration of Reolysin® (Reovirus Serotype-3-dearing Strain) in Patients with Metastatic Melanoma

Galanis E. et al. 
Molecular Therapy 2012
DOI:10.1038/mt.2012.146

Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients

Adair R. et al.
Science Translational Medicine 2012;138(4):138ra77
DOI: 10.1126/scitransmed.3003578

Reovirus Therapy of Tumors with Activated Ras Pathway

Coffey MC et al.
Science. 1998;282(5392):1332-1334
DOI: 10.1126/science.282.5392.1332
PMID: 9812900

REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer

Comins C et al.
Clinical Cancer Research. 2010;16(22):5564-5572
DOI:10.1158/1078-0432.CCR-10-1233         
PMID: 20926400 

A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas

Forsyth P et al.
Molecular Therapy 2007;16(3):627-632
DOI:10.1038/sj.mt.6300403
PMID: 18253152

Intravenous administration of Reolysin, a live replication competent RNA virus is safe in patients with advanced solid tumors

Gollamudi R et al.
Investigational New Drugs 2010;28(5):641-9             
DOI: 10.1007/s10637-009-9279-8
PMID: 19572105 

Two-stage phase 1 dose-escalation study of intratumoral reovirus type 3 Dearing and palliative radiotherapy in patients with advanced cancers

Harrington KJ at al.
Clinical Cancer Research 2010;16(11):3067-77
DOI:10.1158/1078-0432.CCR-10-0054
PMID: 20484020 

Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer

Heinemann L et al.
BioMedCentral June 6 2011; 11:221
DOI:10.1186/1471-2407-11-221
PMID: 21645351 

Systemic administration of reovirus (Reolysin) inhibits growth of human sarcoma xenografts

Hingorani P et al.
Cancer 2011;117(8):1764-1774
DOI: 10.1002/cncr.25741
PMID: 21472724 

Oncolytic reovirus against ovarian and colon cancer

Hirasawa K et al.
Cancer Research 2002;62(6):1696-1701
PMID: 11912142