Oncolytics Biotech, Inc. (ONCY)

Innately Adaptive™

Oncolytics Biotech Inc. is developing pelareorep, a safe and well-tolerated intravenously delivered immuno-oncolytic virus (IOV) that kills cancer through a unique mechanism of action with two components, selective tumor lysis and activation of the innate and adaptive immune systems, creating an inflamed phenotype to treat a variety of solid tumors and hematological malignancies.

What is Immuno-Oncology?

Immuno-oncology is a unique medical approach to treating cancer that utilizes the body's own immune system to fight off cancer cells.

How We're Developing pelareorep as an
Immuno-Oncology Agent

Program 1:
Chemo combinations

Taking advantage of stressed tumor cells to initiate cell lysis.

Program 2: <br> Immunotherapy combinations

Program 2:
Immunotherapy combinations

An approach, and collaboration opportunity, where pelareorep is combined with immunotherapies (such as with Keytruda®, Opdivo® and Tecentriq®).

Program 3: <br>Immunomodulator (IMiDs) / targeted therapy combinations

Program 3:
Immunomodulator (IMiDs) / targeted therapy combinations

Pelareorep is currently being studied in combination with Celgene's Imnovid® & Revlimid® in a first-of-its-kind immunotherapy trial that aims to modulate the immune system to target myeloma.